Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts.

ABSTRACT:

Objective

To systematically test dietary components for association with serum urate levels and to evaluate the relative contributions of estimates of diet pattern and inherited genetic variants to population variance in serum urate levels.

Design

Meta-analysis of cross sectional data from the United States.

Data sources

Five cohort studies.

Review methods

16 760 individuals of European ancestry (8414 men and 8346 women) from the US were included in analyses. Eligible individuals were aged over 18, without kidney disease or gout, and not taking urate lowering or diuretic drugs. All participants had serum urate measurements, dietary survey data, information on potential confounders (sex, age, body mass index, average daily calorie intake, years of education, exe

SUBMITTER: Major TJ 

PROVIDER: S-EPMC6174725 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature