Dynamic changes in intrathymic ILC populations during murine neonatal development.

ABSTRACT: Members of the innate lymphoid cell (ILC) family have been implicated in the development of thymic microenvironments and the recovery of this architecture after damage. However, a detailed characterization of this family in the thymus is lacking. To better understand the thymic ILC compartment, we have utilized multiple in vivo models including the fate mapping of inhibitor of DNA binding-2 (Id2) expression and the use of Id2 reporter mice. Our data demonstrate that ILCs are more prominent immediately after birth, but were rapidly diluted as the T-cell development program increased. As observed in the embryonic thymus, CCR6⁺ NKp46^- lymphoid tissue inducer (LTi) cells were the main ILC3 population present, but numbers of these cells swiftly declined in the neonate and

SUBMITTER: Jones R 

PROVIDER: S-EPMC6174991 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature