⁶⁸Ga-THP-PSMA: A PET Imaging Agent for Prostate Cancer Offering Rapid, Room-Temperature, 1-Step Kit-Based Radiolabeling.

ABSTRACT: The clinical impact and accessibility of ⁶⁸Ga tracers for the prostate-specific membrane antigen (PSMA) and other targets would be greatly enhanced by the availability of a simple, 1-step kit-based labeling process. Radiopharmacy staff are accustomed to such procedures in the daily preparation of ^99mTc radiopharmaceuticals. Currently, chelating agents used in ⁶⁸Ga radiopharmaceuticals do not meet this ideal. The aim of this study was to develop and evaluate preclinically a ⁶⁸Ga radiotracer for imaging PSMA expression that could be radiolabeled simply by addition of ⁶⁸Ga generator eluate to a cold kit. Methods: A conjugate of a tris(hydroxypyridinone) (THP) chelator with the established urea-based PSMA inhibitor was synthesized a

SUBMITTER: Young JD 

PROVIDER: S-EPMC6175039 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature