In Vivo Characterization of 4 ⁶⁸Ga-Labeled Multimeric RGD Peptides to Image α_vβ₃ Integrin Expression in 2 Human Tumor Xenograft Mouse Models.

ABSTRACT: α_vβ₃ integrins play an important role in angiogenesis and cell migration in cancer and are highly expressed on the activated endothelial cells of newly formed blood vessels. Here, we compare the targeting characteristics of 4 ⁶⁸Ga-labeled multimeric cyclic arginine-glycine-aspartate (RGD)-based tracers in an α_vβ₃ integrin-expressing tumor model and a tumor model in which α_vβ₃ integrin is expressed solely on the neovasculature. Methods: Female BALB/c nude mice were subcutaneously injected with SK-RC-52 (α_vβ₃ integrin-positive) or FaDu (α_vβ₃ integrin-negative) tumor cells. ⁶⁸Ga-labeled DOTA-(RGD)₂, TRAP-(RGD)₃, FSC-(RGD)₃,

SUBMITTER: Lobeek D 

PROVIDER: S-EPMC6175042 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature