Bioavailability of Glucoraphanin and Sulforaphane from High-Glucoraphanin Broccoli.

ABSTRACT:

Scope

Broccoli accumulates 4-methylsulphinylbutyl glucosinolate (glucoraphanin) which is hydrolyzed to the isothiocyanate sulforaphane. Through the introgression of novel alleles of the Myb28 transcription factor from Brassica villosa, broccoli genotypes have been developed that have enhanced levels of glucoraphanin. This study seeks to quantify the exposure of human tissues to glucoraphanin and sulforaphane following consumption of broccoli with contrasting Myb28 genotypes.

Methods and results

Ten participants are recruited into a three-phase, double-blinded, randomized crossover trial (NCT02300324), with each phase comprising consumption of 300 g of a soup made from broccoli of one of three Myb28 genotypes (Myb28^B/B , Myb28^B/V , Myb28^V/V ).

SUBMITTER: Sivapalan T 

PROVIDER: S-EPMC6175108 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature