Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost.

ABSTRACT: Many animals experience periods of food shortage in their natural environment. It has been hypothesised that the metabolic responses of animals to naturally-occurring periods of food deprivation may have long-term negative impacts on their subsequent life-history.In particular, reductions in energy requirements in response to fasting may help preserve limited resources but potentially come at a cost of increased oxidative stress. However, little is known about this trade-off since studies of energy metabolism are generally conducted separately from those of oxidative stress.Using a novel approach that combines measurements of mitochondrial function with in vivo levels of hydrogen peroxide (H₂O₂) in brown trout (Salmo trutta), we show here that fasting induces e

SUBMITTER: Salin K 

PROVIDER: S-EPMC6175143 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature