A qualitative signature for early diagnosis of hepatocellular carcinoma based on relative expression orderings.

ABSTRACT:

Background & aims

Currently, using biopsy specimens to confirm suspicious liver lesions of early hepatocellular carcinoma are not entirely reliable because of insufficient sampling amount and inaccurate sampling location. It is necessary to develop a signature to aid early hepatocellular carcinoma diagnosis using biopsy specimens even when the sampling location is inaccurate.

Methods

Based on the within-sample relative expression orderings of gene pairs, we identified a simple qualitative signature to distinguish both hepatocellular carcinoma and adjacent non-tumour tissues from cirrhosis tissues of non-hepatocellular carcinoma patients.

Results

A signature consisting of 19 gene pairs was identified in the training data sets and validated in 2 large collections of sam

SUBMITTER: Ao L 

PROVIDER: S-EPMC6175149 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature