Effect of the COMT Val158Met genotype on lateral prefrontal activations in young children.

ABSTRACT: Low executive function (EF) during early childhood is a major risk factor for developmental delay, academic failure, and social withdrawal. Susceptible genes may affect the molecular and biological mechanisms underpinning EF. More specifically, genes associated with the regulation of prefrontal dopamine may modulate the response of prefrontal neurons during executive control. Several studies with adults and older children have shown that variants of the catechol-O-methyltransferase (COMT) gene are associated with behavioral performance and prefrontal activations in EF tasks. However, the effect of the COMT genotype on prefrontal activations during EF tasks on young children is still unknown. The present study examined whether a common functional polymorphism (Val158Met) in the COMT gene wa

SUBMITTER: Moriguchi Y 

PROVIDER: S-EPMC6175303 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature