ILC2 frequency and activity are inhibited by glucocorticoid treatment via STAT pathway in patients with asthma.

ABSTRACT:

Background

Group 2 innate lymphoid cells (ILC2s) were closely associated with asthma. However, there were no perspective studies about the effects of glucocorticoid on ILC2s in asthma patients. Our objective was to perform a perspective study and evaluate the ILC2 activity after glucocorticoid therapy in asthma patients.

Methods

The asthma and asthma with allergic rhinitis patients were treated with glucocorticoid for 3 months. The circulating ILC2 levels were evaluated. The effects of glucocorticoid on ILC2s and possible signalling pathways were investigated in vitro.

Results

The patients were well-controlled, and the high ILC2 levels were significantly decreased at 1 and 3 months after treatment. Peripheral blood monocytes from allergic patients produced dramatic IL

SUBMITTER: Yu QN 

PROVIDER: S-EPMC6175310 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature