The effect of small doses of fructose and allulose on postprandial glucose metabolism in type 2 diabetes: A double-blind, randomized, controlled, acute feeding, equivalence trial.

ABSTRACT:

Aim

To assess and compare the effect of small doses of fructose and allulose on postprandial blood glucose regulation in type 2 diabetes.

Methods

A double-blind, multiple-crossover, randomized, controlled, acute feeding, equivalence trial in 24 participants with type 2 diabetes was conducted. Each participant was randomly assigned six treatments separated by >1-week washouts. Treatments consisted of fructose or allulose at 0 g (control), 5 g or 10 g added to a 75-g glucose solution. A standard 75-g oral glucose tolerance test protocol was followed with blood samples at -30, 0, 30, 60, 90 and 120 minutes. The primary outcome measure was plasma glucose incremental area under the curve (iAUC).

Results

Allulose significantly reduced plasma glucose iAUC by 8% at 10 g compa

SUBMITTER: Noronha JC 

PROVIDER: S-EPMC6175314 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature