Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial.

ABSTRACT:

Background

Preliminary evidence suggests that diet manipulation may influence motor and nonmotor symptoms in PD, but conflict exists regarding the ideal fat to carbohydrate ratio.

Objectives

We designed a pilot randomized, controlled trial to compare the plausibility, safety, and efficacy of a low-fat, high-carbohydrate diet versus a ketogenic diet in a hospital clinic of PD patients.

Methods

We developed a protocol to support PD patients in a diet study and randomly assigned patients to a low-fat or ketogenic diet. Primary outcomes were within- and between-group changes in MDS-UPDRS Parts 1 to 4 over 8 weeks.

Results

We randomized 47 patients, of which 44 commenced the diets and 38 completed the study (86% completion rate for patients commencing the diets). Th

SUBMITTER: Phillips MCL 

PROVIDER: S-EPMC6175383 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature