Effect of Vitamin D Supplementation on Obesity-Induced Insulin Resistance: A Double-Blind, Randomized, Placebo-Controlled Trial.

ABSTRACT:

Objective

The aim was to investigate whether vitamin D supplementation, combined with a hypocaloric diet, could have an independent effect on insulin sensitivity in subjects with both overweight and hypovitaminosis D. Changes from baseline in anthropometric parameters, body composition, glucose tolerance, and insulin secretion were considered as secondary outcomes.

Methods

Eighteen volunteers who were nondiabetic and vitamin D deficient and had BMI > 25 kg/m² were randomized (1:1) in a double-blind manner to a hypocaloric diet + either oral cholecalciferol at 25,000 IU/wk or placebo for 3 months. Hyperinsulinemic-euglycemic clamp to measure insulin sensitivity was performed at baseline and after intervention.

Results

Body weight in both groups decreased sig

SUBMITTER: Cefalo CMA 

PROVIDER: S-EPMC6175391 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature