Bipolar disorder type I and II show distinct relationships between cortical thickness and executive function.

ABSTRACT:

Objective

Frontal cortical abnormalities and executive function impairment co-occur in bipolar disorder. Recent studies have shown that bipolar subtypes differ in the degree of structural and functional impairments. The relationships between cognitive performance and cortical integrity have not been clarified and might differ across patients with bipolar disorder type I, II, and healthy subjects.

Method

Using a vertex-wise whole-brain analysis, we investigated how cortical integrity, as measured by cortical thickness, correlates with executive performance in patients with bipolar disorder type I, II, and controls (N = 160).

Results

We found focal associations between executive function and cortical thickness in the medial prefrontal cortex in bipolar II patients and c

SUBMITTER: Abe C 

PROVIDER: S-EPMC6175455 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature