Estrogen and mechanical loading-related regulation of estrogen receptor-β and apoptosis in tendinopathy.

ABSTRACT: Female-dominant tendinopathies are musculoskeletal disorders caused by repetitive hand posture and motion; they are considered overuse syndromes. Both external mechanical stress and changes in hormone levels might affect disease progression. We have previously reported that estrogen receptor-β (ER)-β expression was associated with the pathogenesis of de Quervain's disease. To study the underlying mechanisms, a cyclic stretching culture system was applied to tendon tissue from ovariectomized (OVX) rats. Furthermore, a collagenase I-induced rat tendinopathy model was established to examine the association of ER-β with disease progression. Our results showed that ER-β expression and the number of apoptotic cells were higher and associated with disease severity in rats with tendinopathy. Mecha

SUBMITTER: Hsieh JL 

PROVIDER: S-EPMC6175495 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature