Identifying a sufficient core group for trachoma transmission.

ABSTRACT:

Background

In many infectious diseases, a core group of individuals plays a disproportionate role in transmission. If these individuals were effectively prevented from transmitting infection, for example with a perfect vaccine, then the disease would disappear in the remainder of the community. No vaccine has yet proven effective against the ocular strains of chlamydia that cause trachoma. However, repeated treatment with oral azithromycin may be able to prevent individuals from effectively transmitting trachoma.

Methodology/principal findings

Here we assess several methods for identifying a core group for trachoma, assuming varying degrees of knowledge about the transmission process. We determine the minimal core group from a completely specified model, fitted to results fr

SUBMITTER: Lietman TM 

PROVIDER: S-EPMC6175502 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature