MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population.

ABSTRACT:

Objective

To examine the relationship between polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and susceptibility to lung cancer in a female Chinese population.

Method

A hospital-based case-control study of 388 cases and 388 controls was conducted. Two polymorphisms in MTHFR were detected using TaqMan methods.

Results

The MTHFR C677T polymorphism was associated with the risk of lung cancer and lung adenocarcinoma. Carriers with the TT genotype of C677T were observed to have an increased risk of lung cancer and lung adenocarcinoma (the ORs were 1.550 and 1.588, respectively). By contrast, the A1298C polymorphism had a negative relationship with the risk of lung cancer and lung adenocarcinoma; compared with the AA genotype carri

SUBMITTER: Tong W 

PROVIDER: S-EPMC6175546 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature