Patients and investigators prefer measures of absolute risk in subgroups for pragmatic randomized trials.

ABSTRACT:

Objectives

Pragmatic randomized trials are important tools for shared decision-making, but no guidance exists on patients' preferences for types of causal information. We aimed to assess preferences of patients and investigators toward causal effects in pragmatic randomized trials.

Study design and setting

We (a) held three focus groups with patients (n = 23) in Boston, MA; (b) surveyed (n = 12) and interviewed (n = 5) investigators with experience conducting pragmatic trials; and (c) conducted a systematic literature review of pragmatic trials (n = 63).

Results

Patients were distrustful of new-to-market medications unless substantially more effective than existing choices, preferred stratified absolute risks, and valued adherence-adjusted analyses when they expected

SUBMITTER: Murray EJ 

PROVIDER: S-EPMC6175611 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature