TGF-b1 or hypoxia enhance glucose metabolism and lactate production via HIF1A signaling in tendon cells.

ABSTRACT: Purpose/Aim of the study: Healthy tendons are maintained in homeostasis through controlled usage of glucose for energy and redox equilibrium. Tendon cell stress imposed by overuse injury or vascular insufficiency is accompanied by activation of wound healing pathways which facilitate an adaptive response and the restoration of homeostasis. To understand this response at the gene expression level we have studied the in vivo effects of injected TGF-β1 in a murine model of tendinopathy, as well as treatment of murine tendon explants with either TGF-β1 or hypoxia in vitro. METHODS AND RESULTS:We provide evidence (from expression patterns and immunohistochemistry) that both in vivo and in vitro, the stress response in tendon cells may be metabolically controlled in part by glycolytic reprogramm

SUBMITTER: Sikes KJ 

PROVIDER: S-EPMC6175639 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature