Independent predictors of mortality in adolescents ascertained for conduct disorder and substance use problems, their siblings and community controls.

ABSTRACT:

Background and aims

Adolescents with conduct and substance use problems are at increased risk for premature mortality, but the extent to which these risk factors reflect family- or individual-level differences and account for shared or unique variance is unknown. This study examined common and independent contributions to mortality hazard in adolescents ascertained for conduct disorder (CD) and substance use disorder (SUD), their siblings and community controls, hypothesizing that individual differences in CD and SUD severity would explain unique variation in mortality risk beyond that due to clinical/control status and demographic factors.

Design

Mortality analysis in a prospective study (Genetics of Antisocial Drug Dependence Study) that began in 1993.

Setting

Multi

SUBMITTER: Border R 

PROVIDER: S-EPMC6175651 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature