Biodistribution and PET imaging of 89-zirconium labeled cerium oxide nanoparticles synthesized with several surface coatings.

ABSTRACT: Cerium oxide nanoparticles (CONPs) have unique surface chemistry allowing catalyst-like antioxidant properties, and are being investigated for several disease indications in medicine. Studies have utilized surface modified CONPs toward this application, but have been lacking in comprehensive biodistribution and pharmacokinetic data and a direct comparison to uncoated CONPs. We developed an enhanced single-pot synthesis of several coated CONPs and an efficient intrinsic core labeling of CONPs with the clinical PET isotope, zirconium-89, allowing detailed PET imaging and ex vivo biodistribution. All coated [⁸⁹Zr]-CONPs showed benefit in terms of biodistribution compared to uncoated [⁸⁹Zr]-CONPs, while retaining the intrinsic antioxidant properties. Among these, poly(acr

SUBMITTER: McDonagh PR 

PROVIDER: S-EPMC6175665 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature