Physical and numerical phantoms for the validation of brain microstructural MRI: A cookbook.

ABSTRACT: Phantoms, both numerical (software) and physical (hardware), can serve as a gold standard for the validation of MRI methods probing the brain microstructure. This review aims to provide guidelines on how to build, implement, or choose the right phantom for a particular application, along with an overview of the current state-of-the-art of phantoms dedicated to study brain microstructure with MRI. For physical phantoms, we discuss the essential requirements and relevant characteristics of both the (NMR visible) liquid and (NMR invisible) phantom materials that induce relevant microstructural features detectable via MRI, based on diffusion, intra-voxel incoherent motion, magnetization transfer or magnetic susceptibility weighted contrast. In particular, for diffusion MRI, many useful phantom

SUBMITTER: Fieremans E 

PROVIDER: S-EPMC6175674 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature