Simple ruthenium-catalyzed reductive amination enables the synthesis of a broad range of primary amines.

ABSTRACT: The production of primary benzylic and aliphatic amines, which represent essential feedstocks and key intermediates for valuable chemicals, life science molecules and materials, is of central importance. Here, we report the synthesis of this class of amines starting from carbonyl compounds and ammonia by Ru-catalyzed reductive amination using H₂. Key to success for this synthesis is the use of a simple RuCl₂(PPh₃)₃ catalyst that empowers the synthesis of >90 various linear and branched benzylic, heterocyclic, and aliphatic amines under industrially viable and scalable conditions. Applying this catalyst, -NH₂ moiety has been introduced in functionalized and structurally diverse compounds, steroid derivatives and pharmaceuticals. Notewor

SUBMITTER: Senthamarai T 

PROVIDER: S-EPMC6175844 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature