Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control.

ABSTRACT: A deeper epigenomic understanding of spatial organization of cells in human tissues is an important challenge. Here we report the first combined positional analysis of transcriptomes and methylomes across three micro-dissected zones (pericentral, intermediate and periportal) of human liver. We identify pronounced anti-correlated transcriptional and methylation gradients including a core of 271 genes controlling zonated metabolic and morphogen networks and observe a prominent porto-central gradient of DNA methylation at binding sites of 46 transcription factors. The gradient includes an epigenetic and transcriptional Wnt signature supporting the concept of a pericentral hepatocyte regeneration pathway under steady-state conditions. While donors with non-alcoholic fatty liver disease show co

SUBMITTER: Brosch M 

PROVIDER: S-EPMC6175862 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature