Dopamine-endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum.

ABSTRACT: Dopamine modulates striatal synaptic plasticity, a key substrate for action selection and procedural learning. Thus, characterizing the repertoire of activity-dependent plasticity in striatum and its dependence on dopamine is of crucial importance. We recently unraveled a striatal spike-timing-dependent long-term potentiation (tLTP) mediated by endocannabinoids (eCBs) and induced with few spikes (~5-15). Whether this eCB-tLTP interacts with the dopaminergic system remains to be investigated. Here, we report that eCB-tLTP is impaired in a rodent model of Parkinson's disease and rescued by L-DOPA. Dopamine controls eCB-tLTP via dopamine type-2 receptors (D₂R) located presynaptically in cortical terminals. Dopamine-endocannabinoid interactions via D₂R are required for th

SUBMITTER: Xu H 

PROVIDER: S-EPMC6175920 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature