VGLUT2 Functions as a Differential Marker for Hippocampal Output Neurons.

ABSTRACT: The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.

SUBMITTER: Wozny C 

PROVIDER: S-EPMC6176088 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature