Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine.

ABSTRACT: The p53 tumor suppressor plays a major role in controlling the initiation and development of cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 oncogene is a major negative regulator of p53 that inhibits the activity of p53 and reduces its protein stability. MDM2, p53, and the p53-MDM2 pathway represent well-documented targets for preventing and/or treating cancer. Natural products, especially those from medicinal and food plants, are a rich source for the discovery and development of novel therapeutic and preventive agents against human cancers. Many natural product-derived MDM2 inhibitors have shown potent efficacy against various human cancers. In contrast to synthetic small-molecule MDM2 inhibitors, the majority of which have been designed to inhibi

SUBMITTER: Qin JJ 

PROVIDER: S-EPMC6176154 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature