Differentially circulating exosomal microRNAs expression profiling in oral lichen planus.

ABSTRACT: Oral lichen planus (OLP) is a common chronic inflammatory autoimmune disease with unclear etiology. The aim of the present study was to identify the expression profiles of circulating exosomal miRNAs, which have been shown to be potent stimulators of inflammatory and immune responses, in OLP patients. Plasma exosomes were isolated from the patients and healthy individuals, and RAE scoring system was used to evaluate the severity of OLP. Differentially deregulated exosomal miRNAs associated with inflammatory response and autoimmunity in OLP were identified by miScript^® miRNA PCR Array, and the results were confirmed by RT-PCR. The relationship between exosomal miRNAs and RAE scores was then analyzed, and bioinformatics analysis was used to predict the target genes and pathways of

SUBMITTER: Peng Q 

PROVIDER: S-EPMC6176222 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature