Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men.

ABSTRACT:

Background

Increasing body mass index (BMI) is generally associated with loss of metabolic health, although some obese individuals remain metabolically healthy. Among nonobese men, HIV infection has been associated with a lower prevalence of metabolic health.

Methods

We conducted a cross-sectional analysis of 470 HIV-infected and 368 HIV-uninfected men enrolled in the Multicenter AIDS Cohort Study Cardiovascular substudy. Circulating biomarker levels were compared by BMI category and by HIV serostatus. Poisson regression with robust variance determined associations between metabolic health and circulating inflammatory biomarker levels after adjusting for factors previously associated with metabolic health.

Results

HIV-infected men were younger and less likely to be ob

SUBMITTER: Monczor AN 

PROVIDER: S-EPMC6176328 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature