Including historical data in the analysis of clinical trials: Is it worth the effort?

ABSTRACT: Data of previous trials with a similar setting are often available in the analysis of clinical trials. Several Bayesian methods have been proposed for including historical data as prior information in the analysis of the current trial, such as the (modified) power prior, the (robust) meta-analytic-predictive prior, the commensurate prior and methods proposed by Pocock and Murray et al. We compared these methods and illustrated their use in a practical setting, including an assessment of the comparability of the current and the historical data. The motivating data set consists of randomised controlled trials for acute myeloid leukaemia. A simulation study was used to compare the methods in terms of bias, precision, power and type I error rate. Methods that estimate parameters for the betwee

SUBMITTER: van Rosmalen J 

PROVIDER: S-EPMC6176344 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature