Metabolic Syndrome and Amyloid Accumulation in the Aging Brain.

ABSTRACT:

Background

Recent studies show links between metabolic syndrome and Alzheimer's disease (AD) neuropathology. Understanding the link between vascular-related health conditions and dementia will help target at risk populations and inform clinical strategies for early detection and prevention of AD.

Objective

To determine whether metabolic syndrome is associated with global cerebral amyloid-β (Aβ) positivity and longitudinal Aβ accumulation.

Methods

Prospective study of 165 participants who underwent (11)C-Pittsburgh compound B (PiB) PET neuroimaging to measure Aβ, from June 2005 to May 2016. Metabolic syndrome was defined using the revised Third Adults Treatment Panel of the National Cholesterol Education Program criteria. Participants were classified as PiB+/-. Linear

SUBMITTER: Gomez G 

PROVIDER: S-EPMC6176485 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature