Optimization of macaque brain DMRI connectome by neuron tracing and myelin stain data.

ABSTRACT: Accurate assessment of connectional anatomy of primate brains can be an important avenue to better understand the structural and functional organization of brains. To this end, numerous connectome projects have been initiated to create a comprehensive map of the connectional anatomy over a large spatial expanse. Tractography based on diffusion MRI (dMRI) data has been used as a tool by many connectome projects in that it is widely used to visualize axonal pathways and reveal microstructural features on living brains. However, the measures obtained from dMRI are indirect inference of microstructures. This intrinsic limitation reduces the reliability of dMRI in constructing connectomes for brains. In this work, we proposed a framework to increase the accuracy of constructing a dMRI-based con

SUBMITTER: Zhang T 

PROVIDER: S-EPMC6176488 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature