Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCδ Isoform Activation.

ABSTRACT:

Rationale

Activation of monocytes/macrophages by hyperlipidemia associated with diabetes mellitus and obesity contributes to the development of atherosclerosis. PKCδ (protein kinase C δ) expression and activity in monocytes were increased by hyperlipidemia and diabetes mellitus with unknown consequences to atherosclerosis.

Objective

To investigate the effect of PKCδ activation in macrophages on the severity of atherosclerosis.

Methods and results

PKCδ expression and activity were increased in Zucker diabetic rats. Mice with selective deletion of PKCδ in macrophages were generated by breeding PKCδ flox/flox mice with LyzM-Cre and ApoE^-/- mice (MPKCδKO/ApoE^-/- mice) and studied in atherogenic (AD) and high-fat diet (HFD). Mice fed AD and

SUBMITTER: Li Q 

PROVIDER: S-EPMC6176491 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature