Effects of social defeat stress on dopamine D2 receptor isoforms and proteins involved in intracellular trafficking.

ABSTRACT:

Background

Chronic social defeat stress induces depression and anxiety-like behaviors in rodents and also responsible for differentiating defeated animals into stress susceptible and resilient groups. The present study investigated the effects of social defeat stress on a variety of behavioral parameters like social behavior, spatial learning and memory and anxiety like behaviors. Additionally, the levels of various dopaminergic markers, including the long and short form of the D2 receptor, and total and phosphorylated dopamine and cyclic adenosine 3',5'-monophosphate regulated phosphoprotein-32, and proteins involved in intracellular trafficking were assessed in several key brain regions in young adult mice.

Methods

Mouse model of chronic social defeat was established by re

SUBMITTER: Prabhu VV 

PROVIDER: S-EPMC6176509 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature