Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging.

ABSTRACT: Age-related changes in striatal function are potentially important for predicting declining memory performance over the adult life span. Here, we used fMRI to measure functional connectivity of caudate subfields with large-scale association networks and positron emission tomography to measure striatal dopamine transporter (DAT) density in 51 older adults (age 65-86 years) who received annual cognitive testing for up to 7 years (mean = 5.59, range 2-7 years). Analyses showed that cortical-caudate functional connectivity was less differentiated in older compared with younger adults (n = 63, age 18-32 years). Unlike in younger adults, the central lateral caudate was less strongly coupled with the frontal parietal control network in older adults. Older adults also showed less "decouplin

SUBMITTER: Rieckmann A 

PROVIDER: S-EPMC6176586 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature