Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding.

ABSTRACT: The hippocampus plays key roles in cognition and affect and serves as a model system for structure/function studies in animals. So far, its complex anatomy has challenged investigations targeting its substructural organization in humans. State-of-the-art MRI offers the resolution and versatility to identify hippocampal subfields, assess its microstructure, and study topographical principles of its connectivity in vivo. We developed an approach to unfold the human hippocampus and examine spatial variations of intrinsic functional connectivity in a large cohort of healthy adults. In addition to mapping common and unique connections across subfields, we identified two main axes of subregional connectivity transitions. An anterior/posterior gradient followed long-axis landmarks and metaanalyti

SUBMITTER: Vos de Wael R 

PROVIDER: S-EPMC6176604 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature