Synchronized mechanical oscillations at the cell-matrix interface in the formation of tensile tissue.

ABSTRACT: The formation of uniaxial fibrous tissues with defined viscoelastic properties implies the existence of an orchestrated mechanical interaction between the cytoskeleton and the extracellular matrix. This study addresses the nature of this interaction. The hypothesis is that this mechanical interplay underpins the mechanical development of the tissue. In embryonic tendon tissue, an early event in the development of a mechanically robust tissue is the interaction of the pointed tips of extracellular collagen fibrils with the fibroblast plasma membrane to form stable interface structures (fibripositors). Here, we used a fibroblast-generated tissue that is structurally and mechanically matched to embryonic tendon to demonstrate homeostasis of cell-derived and external strain-derived tension ove

SUBMITTER: Holmes DF 

PROVIDER: S-EPMC6176648 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature