Sleep and EEG Power Spectral Analysis in Three Transgenic Mouse Models of Alzheimer's Disease: APP/PS1, 3xTgAD, and Tg2576.

ABSTRACT:

Background

Sleep disturbances have long been associated with Alzheimer's disease (AD), and there is a growing interest in how these disturbances might impact AD pathophysiology. Despite this growing interest, surprisingly little is known about how sleep architecture and the broader neuronal network are affected in widely used transgenic mouse models of AD.

Objective

We analyzed sleep and electroencephalography (EEG) power in three transgenic mouse models of AD, using identical and commercially available hardware and analytical software. The goal was to assess the suitability of these mouse lines to model sleep and the broader neuronal network dysfunction measured by EEG in AD.

Methods

Tg2576, APP/PS1, and 3xTgAD transgenic AD mice were studied using in vivo EEG record

SUBMITTER: Kent BA 

PROVIDER: S-EPMC6176720 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature