Efficient construction of match strength distributions for uncertain multi-locus genotypes.

ABSTRACT: Natural variation in biological evidence leads to uncertain genotypes. Forensic comparison of a probabilistic genotype with a person's reference gives a numerical strength of DNA association. The distribution of match strength for all possible references usefully represents a genotype's potential information. But testing more genetic loci exponentially increases the number of multi-locus possibilities, making direct computation infeasible. At each locus, Bayesian probability can quickly assemble a match strength random variable. Multi-locus match strength is the sum of these independent variables. A multi-locus genotype's match strength distribution is efficiently constructed by convolving together the separate locus distributions. This convolution construction can accurately collate all t

SUBMITTER: Perlin MW 

PROVIDER: S-EPMC6176789 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature