Characterization of diabetic neuropathy progression in a mouse model of type 2 diabetes mellitus.

ABSTRACT: Diabetes mellitus (DM) is one of most common chronic diseases with an increasing incidence in most countries. Diabetic neuropathy (DN) is one of the earliest and main complications of diabetic patients, which is characterized by progressive, distal-to-proximal degeneration of peripheral nerves. The cellular and molecular mechanisms that trigger DN are highly complex, heterogeneous and not completely known. Animal models have constituted a valuable tool for understanding diabetes pathophysiology; however, the temporal course of DN progression in animal models of type 2 diabetes (T2DM) is not completely understood. In this work, we characterized the onset and progression of DN in BKS diabetic (db/db) mice, including the main functional and histological features observed in the human d

SUBMITTER: De Gregorio C 

PROVIDER: S-EPMC6176942 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature