A model of chronic enthesitis and new bone formation characterized by multimodal imaging.

ABSTRACT: Enthesitis is a key feature of several different rheumatic diseases. Its pathophysiology is only partially known due to the lack of access to human tissue and the shortage of reliable animal models for enthesitis. Here, we aimed to develop a model that mimics the effector phase of enthesitis and reliably leads to inflammation and new bone formation. Enthesitis was induced by local injection of monosodium urate (MSU) crystals into the metatarsal entheses of wild-type (WT) or oxidative-burst-deficient (Ncf1**) mice. Quantitative variables of inflammation (edema, swelling) and vascularization (tissue perfusion) were assessed by magnetic resonance imaging (MRI), bone-forming activity by [¹⁸F]-fluoride positron emission tomography (PET), and destruction of cortical bone and ne

SUBMITTER: Czegley C 

PROVIDER: S-EPMC6176995 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature