Independent effects of dietary fat and sucrose content on chondrocyte metabolism and osteoarthritis pathology in mice.

ABSTRACT: Obesity is one of the most significant risk factors for knee osteoarthritis. However, therapeutic strategies to prevent or treat obesity-associated osteoarthritis are limited because of uncertainty about the etiology of disease, particularly with regard to metabolic factors. High-fat-diet-induced obese mice have become a widely used model for testing hypotheses about how obesity increases the risk of osteoarthritis, but progress has been limited by variation in disease severity, with some reports concluding that dietary treatment alone is insufficient to induce osteoarthritis in mice. We hypothesized that increased sucrose content of typical low-fat control diets contributes to osteoarthritis pathology and thus alters outcomes when evaluating the effects of a high-fat diet. We tested this

SUBMITTER: Donovan EL 

PROVIDER: S-EPMC6176996 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature