Effects of genetic deletion versus pharmacological blockade of the LPA₁ receptor on depression-like behaviour and related brain functional activity.

ABSTRACT: Animal models of psychopathology are particularly useful for studying the neurobiology of depression and characterising the subtypes. Recently, our group was the first to identify a possible relationship between the LPA₁ receptor and a mixed anxiety-depression phenotype. Specifically, maLPA₁-null mice exhibited a phenotype characterised by depressive and anxious features. However, the constitutive lack of the gene encoding the LPA₁ receptor (Lpar1) can induce compensatory mechanisms that might have resulted in the observed deficits. Therefore, in the present study, we have compared the impact of permanent loss and acute pharmacological inhibition of the LPA₁ receptor on despair-like behaviours and on the functional brain map associated wit

SUBMITTER: Moreno-Fernandez RD 

PROVIDER: S-EPMC6177006 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature