Gene expression in response to optical defocus of opposite signs reveals bidirectional mechanism of visually guided eye growth.

ABSTRACT: Myopia (nearsightedness) is the most common eye disorder, which is rapidly becoming one of the leading causes of vision loss in several parts of the world because of a recent sharp increase in prevalence. Nearwork, which produces hyperopic optical defocus on the retina, has been implicated as one of the environmental risk factors causing myopia in humans. Experimental studies have shown that hyperopic defocus imposed by negative power lenses placed in front of the eye accelerates eye growth and causes myopia, whereas myopic defocus imposed by positive lenses slows eye growth and produces a compensatory hyperopic shift in refractive state. The balance between these two optical signals is thought to regulate refractive eye development; however, the ability of the retina to recognize the sign

SUBMITTER: Tkatchenko TV 

PROVIDER: S-EPMC6177118 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature