Evaluation of antivirals against tick-borne encephalitis virus in organotypic brain slices of rat cerebellum.

ABSTRACT: Neurotropic tick borne encephalitis virus (TBEV) causes life-threatening disease, and accounts for most cases of tick-transmitted viral infections in Central and Eastern Europe and Russia. No specific treatment for TBEV infections exists, and vaccination is recommended for people at risk. So far, various nucleoside analogues have been investigated in vitro as potential candidates for treatment of TBEV infections. However, in vitro experiments with more complex cell culture systems, such as organotypic culture slices which model the sophisticated architecture of the target tissue are lacking. Using TBEV as a model, we investigated the suitability of rat organotypic cerebellum slices (OCS) to study the effectiveness of nucleoside analogues with a well-known anti-TBEV activity. In these OCS,

SUBMITTER: Lenz N 

PROVIDER: S-EPMC6177190 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature