Mitochondria reorganization upon proliferation arrest predicts individual yeast cell fate.

ABSTRACT: Most cells spend the majority of their life in a non-proliferating state. When proliferation cessation is irreversible, cells are senescent. By contrast, if the arrest is only temporary, cells are defined as quiescent. These cellular states are hardly distinguishable without triggering proliferation resumption, hampering thus the study of quiescent cells properties. Here we show that quiescent and senescent yeast cells are recognizable based on their mitochondrial network morphology. Indeed, while quiescent yeast cells display numerous small vesicular mitochondria, senescent cells exhibit few globular mitochondria. This allowed us to reconsider at the individual-cell level, properties previously attributed to quiescent cells using population-based approaches. We demonstrate that cell's pro

SUBMITTER: Laporte D 

PROVIDER: S-EPMC6177259 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature