Gray matter volume covariance patterns associated with gait speed in older adults: a multi-cohort MRI study.

ABSTRACT: Accelerated gait decline in aging is associated with many adverse outcomes, including an increased risk for falls, cognitive decline, and dementia. Yet, the brain structures associated with gait speed, and how they relate to specific cognitive domains, are not well-understood. We examined structural brain correlates of gait speed, and how they relate to processing speed, executive function, and episodic memory in three non-demented and community-dwelling older adult cohorts (Overall N = 352), using voxel-based morphometry and multivariate covariance-based statistics. In all three cohorts, we identified gray matter volume covariance patterns associated with gait speed that included brain stem, precuneus, fusiform, motor, supplementary motor, and prefrontal (particularly ventrolateral prefro

SUBMITTER: Blumen HM 

PROVIDER: S-EPMC6177326 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature