Development of a Molecular Adjuvant to Enhance Antigen-Specific CD8⁺ T Cell Responses.

ABSTRACT: Despite promising progress in malaria vaccine development, an efficacious subunit vaccine against P. falciparum remains to be licensed and deployed. This study aimed to improve on the immunogenicity of the leading liver-stage vaccine candidate (ChAd63-MVA ME-TRAP), known to confer protection by eliciting high levels of antigen-specific CD8⁺ T cells. We previously showed fusion of ME-TRAP to the human MHC class II invariant chain (Ii) could enhance CD8⁺ T cell responses in non-human primates, but did not progress to clinical testing due to potential risk of auto-immunity by vaccination of humans with a self-antigen. Initial immunogenicity analyses of ME-TRAP fused to subdomains of the Ii showed that the Ii transmembrane domain alone can enhance CD8⁺ T cell r

SUBMITTER: Halbroth BR 

PROVIDER: S-EPMC6177389 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature