Using long term mortality to determine which perioperative risk factors of mortality following hip and knee replacement may be causal.

ABSTRACT: Observational studies have identified surgical factors that are associated with a reduced risk of mortality after joint replacement. It is not clear whether these are causal or reflect patient selection. Data on the first primary hip (n = 424,156) and knee replacements (n = 469,989) performed for osteoarthritis in the National Joint Registry were analysed. Flexible parametric survival modelling was used to determine if risk factors for mortality in the perioperative period persisted. To explore selection bias, standardised mortality ratios were calculated for all-cause, respiratory and smoking related cancer mortality using population rates. Selection was apparent for hip resurfacing, combined spinal and general anaesthetic and unicondylar knee implants; reduced mortality was observed for

SUBMITTER: Hunt LP 

PROVIDER: S-EPMC6177450 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature