Murine transcription factor Math6 is a regulator of placenta development.

ABSTRACT: The murine basic helix-loop-helix transcription (bHLH) factor mouse atonal homolog 6 (Math6) is expressed in numerous organs and supposed to be involved in several developmental processes. However, so far neither all aspects nor the molecular mechanisms of Math6 function have been explored exhaustively. To analyze the in vivo function of Math6 in detail, we generated a constitutive knockout (KO) mouse (Math6^-/-) and performed an initial histological and molecular biological investigation of its main phenotype. Pregnant Math6^-/- females suffer from a disturbed early placental development leading to the death of the majority of embryos independent of the embryonic Math6 genotype. A few placentas and fetuses survive the severe uterine hemorrhagic events at late mid-gesta

SUBMITTER: Boing M 

PROVIDER: S-EPMC6177472 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature