Spatial correlations between MRI-derived wall shear stress and vessel wall thickness in the carotid bifurcation.

ABSTRACT: BACKGROUND:To explore the possibility of creating three-dimensional (3D) estimation models for patient-specific wall thickness (WT) maps using patient-specific and cohort-averaged WT, wall shear stress (WSS), and vessel diameter maps in asymptomatic atherosclerotic carotid bifurcations. METHODS:Twenty subjects (aged 75?±?6 years [mean?±?standard deviation], eight women) underwent a 1.5-T MRI examination. Non-gated 3D phase-contrast gradient-echo images and proton density-weighted echo-planar images were retrospectively assessed for WSS, diameter estimation, and WT measurements. Spearman's ? and scatter plots were used to determine correlations between individual WT, WSS, and diameter maps. A bootstrapping technique was used to determine correlations between 3D cohort-averaged WT, WSS, and diameter maps. Linear regression between the cohort-averaged WT, WSS, and diameter maps was used to predict individual 3D WT. RESULTS:Spearman's ? averaged over the subjects was -?0.24?±?0.18 (p?

SUBMITTER: van Ooij P 

PROVIDER: S-EPMC6177500 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature